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Science. 2002 Sep 27;297(5590):2270-5.

Gene expression during the life cycle of Drosophila melanogaster.

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Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA.

Erratum in

  • Science 2002 Nov 8;298(5596):1172.


Molecular genetic studies of Drosophila melanogaster have led to profound advances in understanding the regulation of development. Here we report gene expression patterns for nearly one-third of all Drosophila genes during a complete time course of development. Mutations that eliminate eye or germline tissue were used to further analyze tissue-specific gene expression programs. These studies define major characteristics of the transcriptional programs that underlie the life cycle, compare development in males and females, and show that large-scale gene expression data collected from whole animals can be used to identify genes expressed in particular tissues and organs or genes involved in specific biological and biochemical processes.

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