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Blood. 2002 Oct 15;100(8):2692-6.

Current molecular models for NADPH oxidase regulation by Rac GTPase.

Author information

1
Departments of Immunology and Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. bokoch@scripps.edu

Abstract

Reactive oxygen species (ROS) have been increasingly recognized as important components of cell signaling in addition to their well-established roles in host defense. The formation of ROS in phagocytic and nonphagocytic cells involves membrane-localized and Rac guanosine triphosphatase (GTPase)-regulated reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase(s). We discuss here the current molecular models for Rac GTPase action in the control of the phagocytic leukocyte NADPH oxidase. As a mechanistically detailed example of Rac GTPase signaling, the NADPH oxidase provides a potential paradigm for signaling by Rho family GTPases in general.

PMID:
12351373
DOI:
10.1182/blood-2002-04-1149
[Indexed for MEDLINE]

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