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Mech Dev. 2002 Oct;118(1-2):225-8.

Expression of the LIM-homeodomain gene Lmx1a (dreher) during development of the mouse nervous system.

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UPR 2197, Développement, Evolution, Plasticité du Système Nerveux, Institut de Neurobiologie Alfred FESSARD, C.N.R.S., Avenue de la Terrasse, 91198 GIF-sur-YVETTE cedex, France.


The expression pattern of Lmx1a, a LIM-homeodomain gene disrupted in the dreher mouse neurological mutant, is described during development. Lmx1a is predominantly expressed in the developing nervous system from embryonic day E8.5 to adulthood, in restricted areas. Major expression domains include the dorsal midline (roof plate) of the neural tube, the cortical hem, the otic vesicles, the developing cerebellum and the notochord. The Lmx1a expression pattern is therefore well correlated with the various aspects of the phenotype of the dreher mutant mice.

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