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Shengzhi Yu Biyun. 1991 Aug;11(3):17-21.

[The effects and mechanism of norethisterone and megestrol on lipoprotein metabolism in rats].

[Article in Chinese]



The authors studied rat lipoprotein metabolism treated by norethisterone on megestrol (2 mg/rat/day) for 15 days). The results were as follows. Female SD rats treated with norethisterone had lower plasma TC, LDL-C, and HDL-C. Those treated with megestrol showed opposite results. To explain this outcome, the authors measured the concentration of HDL-C and VLDL-C turnover by injecting 125 I-labelled human LDL into rats. These results showed that megestrol could increase the synthesis and/or secretion of HDL-C and VLDL-C from rat liver and decrease the binding and degradation of rat 125 I-HDL in rat hepatocytes, while the uptake and degradation of human 125 I-LDL was unchanged. Norethisterone could inhibit the synthesis and secretion of HDL-C and VLDL-C from rat liver; it could also inhibit the uptake and degradation of LDL but the former inhibition was dominant. If norethisterone and megestrol were not used continuously, the changed metabolism would return to normal. (author's modified)

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