Format

Send to

Choose Destination
Am J Clin Nutr. 2002 Oct;76(4):865-72.

Dietary catechin delays tumor onset in a transgenic mouse model.

Author information

1
Departments of Viticulture and Enology, University of California, Davis 95616, USA. seebeler@ucdavis.edu

Abstract

BACKGROUND:

Evidence exists that red wine, which contains a large array of polyphenols, is protective against cardiovascular disease and possibly cancer.

OBJECTIVE:

We tested the hypothesis that catechin, the major monomeric polyphenol in red wine, can delay tumor onset in transgenic mice that spontaneously develop tumors.

DESIGN:

Mice were fed a nutritionally complete amino acid-based diet supplemented with (+)-catechin (0-8 mmol/kg diet) or alcohol-free solids from red wine. Mice were examined daily; the age at which a first tumor appeared was recorded as the age at tumor onset. Plasma catechin and metabolite concentrations were quantified at the end of the study.

RESULTS:

Dietary catechin significantly delayed tumor onset; a positive, linear relation was observed between the age at tumor onset and either the amount of dietary catechin (r(2) = 0.761, P < 0.001) or plasma catechin and metabolite concentrations (r(2) = 0.408, P = 0.003). No significant effects on tumor onset were observed when mice consumed a diet supplemented with wine solids containing <0.22 mmol catechin/kg diet, whereas a previous study showed that wine solids with a similar total polyphenol concentration but containing approximately 4 times more catechin significantly delayed tumor onset by approximately 30 d compared with a control diet. The catechin composition of the wines is directly related to processing conditions during vinification.

CONCLUSIONS:

Physiologic intakes of specific dietary polyphenols, such as catechin, may play an important role in cancer chemoprevention. Wines have different polyphenol concentrations and compositions; therefore, the overall health benefits of individual wines differ.

PMID:
12324302
DOI:
10.1093/ajcn/76.4.865
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center