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Curr Opin Pharmacol. 2002 Oct;2(5):587-94.

Peptide-mediated cell delivery: application in protein target validation.

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AstraZeneca Pharmaceuticals, Enabling Science and Technology - Biology, 19F19 Mereside, Alderley Park, Macclesfield, Cheshire, UK.


Recent reports have suggested that conjugation of peptides, proteins and antisense to short highly basic peptides, such as TAT, antennapedia and transportan, results in their rapid translocation into cells. Importantly, these conjugates have been shown to exert actions in a number of animal models suggesting their general utility for the determination of protein function in vitro and in vivo.

[Indexed for MEDLINE]

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