Format

Send to

Choose Destination
Curr Opin Pharmacol. 2002 Oct;2(5):501-6.

The bacterial ribosome, a promising focus for structure-based drug design.

Author information

1
RiboTargets, Granta Park, Abington, Cambridge, UK. dknowles@ribotargets.com

Abstract

Recent crystal structures of the bacterial ribosome have identified the complex molecular interactions involved in antibiotic-ribosome recognition. Insights into the binding of aminoglycosides, macrolides, tetracyclines and other antibiotics provide opportunities for computational, structure-based approaches to be used in the design of appropriate modifications to existing antibiotics as well as in the discovery of completely new drug classes.

PMID:
12324250
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center