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Curr Opin Pharmacol. 2002 Oct;2(5):501-6.

The bacterial ribosome, a promising focus for structure-based drug design.

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RiboTargets, Granta Park, Abington, Cambridge, UK.


Recent crystal structures of the bacterial ribosome have identified the complex molecular interactions involved in antibiotic-ribosome recognition. Insights into the binding of aminoglycosides, macrolides, tetracyclines and other antibiotics provide opportunities for computational, structure-based approaches to be used in the design of appropriate modifications to existing antibiotics as well as in the discovery of completely new drug classes.

[Indexed for MEDLINE]

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