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Am J Hum Genet. 2002 Oct;71(4):759-76. Epub 2002 Sep 23.

High-resolution patterns of meiotic recombination across the human major histocompatibility complex.

Author information

1
Basic Research Program, SAIC-Frederick, National Cancer Institute, Frederick, MD 21702, USA.

Abstract

Definitive characteristics of meiotic recombination events over large (i.e., >1 Mb) segments of the human genome remain obscure, yet they are essential for establishing the haplotypic structure of the genome and for efficient mapping of complex traits. We present a high-resolution map of recombination at the kilobase level across a 3.3-Mb interval encompassing the major histocompatibility complex (MHC). Genotyping of 20,031 single sperm from 12 individuals resulted in the identification and fine mapping of 325 recombinant chromosomes within genomic intervals as small as 7 kb. Several principal characteristics of recombination in this region were observed: (1) rates of recombination can differ significantly between individuals; (2) intense hot spots of recombination occur at least every 0.8 Mb but are not necessarily evenly spaced; (3) distribution in the location of recombination events can differ significantly among individuals; (4) between hot spots, low levels of recombination occur fairly evenly across 100-kb segments, suggesting the presence of warm spots of recombination; and (5) specific sequence motifs associate significantly with recombination distribution. These data provide a plausible model for recombination patterns of the human genome overall.

PMID:
12297984
PMCID:
PMC378534
DOI:
10.1086/342973
[Indexed for MEDLINE]
Free PMC Article

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