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Di Yi Jun Yi Da Xue Xue Bao. 2002 Jun;22(6):545-7.

Effect of parenteral nutrition with L-arginine supplementation on postoperative immune function in patients with colorectal cancer.

Author information

1
Department of General Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.

Abstract

OBJECTIVE:

To study the effects of parenteral nutrition (PN) supplemented with L-arginine on the immune function of patients with colorectal cancer after operation.

METHODS:

Forty randomly chosen patients with colorectal cancer were enrolled in this study, who received either standard PN or PN supplemented with 20 g/d L-arginine for 7 d after surgical removal of the tumors. Tests of the immune function (CD3(+), CD4(+), CD8(+), CD4(+)/CD8(+), interleukin-2R, natural killer cells, C3, C4, CH50, IgA, IgM, IgG) were performed preoperatively and at different time periods postoperatively.

RESULTS:

Data analysis with ANOVA demonstrated immune suppression in the patients before operation, and the condition was improved (as evidenced by increased CD4(+),CD4(+)/CD8(+), natural killer cells and interleukin-2R levels) in L-arginine group as compared with the results in the control group at days 4 and 7 (P<0.05).

CONCLUSION:

Arginine can improve the immune function in patients with colorectal cancer after operation and enhance PN effect.

PMID:
12297482
[Indexed for MEDLINE]

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