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FEBS Lett. 2002 Sep 25;528(1-3):3-4.

Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis?

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Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.


A gene family containing a longevity assurance gene (Lag1p) motif is described. Database searches revealed >40 members of this family of transmembrane proteins, two of which have recently been shown to regulate the synthesis of ceramide, a lipid second messenger involved in a variety of cellular processes. We speculate that other family members, some of which contain a Hox domain, may also be involved in the synthesis of specific ceramide pools, perhaps explaining the role of longevity assurance genes in regulating development.

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