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Bioorg Med Chem Lett. 2002 Oct 21;12(20):2963-7.

Novel substituted 4-aminomethylpiperidines as potent and selective human beta3-agonists. Part 2: arylethanolaminomethylpiperidines.

Author information

1
Chemical Sciences, Wyeth Research, 500 Arcola Rd, Collegeville, PA 19426, USA. steffar@wyeth.com

Abstract

The synthesis and SAR of a series of beta3 adrenoreceptor agonists based on a novel template derived from 4-aminomethylpiperidine coupled with a common pharmacophore, arylethylamine, is described. This combination led to the identification of human beta3 adrenoreceptor agonists with in vivo activity in a transgenic mouse model.

PMID:
12270184
DOI:
10.1016/s0960-894x(02)00608-x
[Indexed for MEDLINE]

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