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Bioorg Med Chem Lett. 2002 Oct 21;12(20):2863-6.

Neuroprotection against ischemic brain injury conferred by a novel nitrate ester.

Author information

1
Department of Pharmacology and Toxicology, Queen's University, Kingston, ON, Canada.

Abstract

Nitrates exhibit a selectivity of action in different tissue types not fully recognized: in particular, the neuromodulatory and cardiovascular properties can be dissociated. A novel nitrate showed relatively weak systemic effects, but in the middle cerebral artery occlusion rat model of focal ischemia, reduced the cerebral infarct by 60-70% when administered 4 h after the onset of ischemia.

PMID:
12270164
DOI:
10.1016/s0960-894x(02)00631-5
[Indexed for MEDLINE]

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