Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2002 Oct 21;12(20):2829-31.

Synthesis and kinase inhibitory activity of 3'-(S)-epi-K-252a.

Author information

1
Department of Medicinal Chemistry, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USA. dgingric@cephalon.com

Abstract

The 3'-epi diastereomer of K-252a was synthesized with the goal of evaluating the stereochemical requirements of the 3'-sugar alcohol on kinase inhibitory activity. Inverting the 3'-alcohol resulted in a 20 nM inhibitor of VEGFR2 and a 1 nM inhibitor of TrkA tyrosine kinase.

PMID:
12270156
DOI:
10.1016/s0960-894x(02)00638-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center