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Biochem Biophys Res Commun. 2002 Sep 27;297(3):468-72.

Photosensitizing effect of protoporphyrin IX in pigmented melanoma of mice.

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Department of Biophysics, Institute for Cancer Research, The Norwegian Radium Hospital, NO-0310 Montebello, Oslo, Norway.


No fluorescence of protoporphyrin IX (PpIX) was measured using a fiber optic probe in pigmented B16F10 melanoma in mice after topical application of 5-aminolevulinic acid methylester (ALA-Me). However, chemical extraction of tissues excised from mice after intratumoral administration of ALA-Me or its parent compound ALA revealed that this tumor had the capability to produce PpIX. Small amounts of endogenous porphyrins, mainly PpIX, were found in the melanoma not treated with these drugs. Topical application of ALA-Me followed by exposure with laser light (633nm) delayed the growth of the tumors slightly. Light alone also had a significant effect on the tumor growth.

[Indexed for MEDLINE]

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