Recurrence of allergic rhinitis, previously alleviated with allergen immunotherapy, after autologous bone marrow transplant

Ann Allergy Asthma Immunol. 2002 Sep;89(3):316-8. doi: 10.1016/S1081-1206(10)61961-8.

Abstract

Background: Several associations between immunoglobulin E and bone marrow transplantation (BMT) have been reported.

Objective: A patient whose allergic rhinitis (AR) resolved after allergen immunotherapy (AIT) but recurred after the patient received an autologous BMT is reported.

Methods: Allergy skin tests were performed before AIT began and after 4 years of therapy. Skin tests were repeated after a recurrence of symptoms 6 years later after an autologous BMT for breast cancer.

Results: Six years of AIT led to a near complete resolution of AR symptoms. Skin tests showed a marked reduction in reactivity to allergens in the AIT. After an additional 6-year symptom-free interval off AIT, symptoms returned after the BMT. Repeat skin tests showed a marked increase in reactivity.

Conclusions: Patients reconstituting their immune systems after autologous BMT may have a recurrence of AR previously suppressed with AIT.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Allergens / therapeutic use
  • Bone Marrow Transplantation / adverse effects*
  • Desensitization, Immunologic
  • Female
  • Humans
  • Recurrence
  • Rhinitis, Allergic, Perennial / diagnosis
  • Rhinitis, Allergic, Perennial / etiology*
  • Rhinitis, Allergic, Perennial / therapy
  • Rhinitis, Allergic, Seasonal / diagnosis
  • Rhinitis, Allergic, Seasonal / etiology*
  • Rhinitis, Allergic, Seasonal / therapy
  • Skin Tests

Substances

  • Allergens