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Nat Immunol. 2002 Oct;3(10):944-50. Epub 2002 Sep 3.

B cells regulate autoimmunity by provision of IL-10.

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1
University of Edinburgh, Institute of Cell, Animal and Population Biology, King's Buildings West Mains Road, Edinburgh EH9 3JT, UK.

Abstract

To assess the importance of B cell control of T cell differentiation, we analyzed the course of the T helper type 1 (T(H)1)-driven disease experimental autoimmune encephalomyelitis in mice with an altered B cell compartment. We found that recovery was dependent on the presence of autoantigen-reactive B cells. B cells from recovered mice produced interleukin 10 (IL-10) in response to autoantigen. With a bone marrow chimeric system, we generated mice in which IL-10 deficiency was restricted to B cells but not T cells. In the absence of IL-10 production by B cells, the pro-inflammatory type 1 immune response persisted and mice did not recover. These data show that B cell-derived IL-10 plays a key role in controlling autoimmunity.

PMID:
12244307
DOI:
10.1038/ni833
[Indexed for MEDLINE]
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