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Hepatogastroenterology. 2002 Sep-Oct;49(47):1457-60.

The effect of stress on gastric emptying rate measured with a radionuclide tracer.

Author information

1
Laboratory for Human Anatomy, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium. mistiaen@ruca.ua.ac.be

Abstract

BACKGROUND/AIMS:

Stress can delay gastric emptying rate. This phenomenon has not yet been investigated with a physiological solid test meal or a regional analysis.

METHODOLOGY:

We investigated the gastric emptying rate in beagle dogs using a radio-labeled solid test meal and a gamma camera. The transport to an unknown environment served as a stress stimulus. This offers the advantage to mimic fairly well the clinical situation just before a diagnostic or therapeutic procedure. Control values were obtained after the third investigation, in which all dogs were accustomed to the environment.

RESULTS:

Regional analysis of the emptying curves from the whole gastric region revealed that the length of the lag phase increased with stress, but the post-initial emptying rate remained unchanged. Emptying of the fundus changed hardly, but the antropyloral motor activity decreased during stress.

CONCLUSIONS:

Gastric emptying rate is impeded during stress. It is necessary to limit the unnatural stress-stimuli, in order to mimic the clinical situation. Measurement techniques that influence directly gastric emptying or act as a stress-stimulus by themselves are undesirable. A radionuclide solid test meal is preferable and a regional analysis reveals the impairment of the antral motility as the mechanism of the delay of gastric emptying.

PMID:
12239966
[Indexed for MEDLINE]

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