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Nature. 2002 Sep 19;419(6904):270.

Eukaryotic evolution: early origin of canonical introns.

Author information

1
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada. simpson@hades.biochem.da.ca

Abstract

Spliceosomal introns, one of the hallmarks of eukaryotic genomes, were thought to have originated late in evolution and were assumed not to exist in eukaryotes that diverged early -- until the discovery of a single intron with an aberrant splice boundary in the primitive 'protozoan' Giardia. Here we describe introns from a close relative of Giardia, Carpediemonas membranifera, that have boundary sequences of the normal eukaryotic type, indicating that canonical introns are likely to have arisen very early in eukaryotic evolution.

PMID:
12239559
DOI:
10.1038/419270a
[Indexed for MEDLINE]

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