Abstract
The mutations that are responsible for fluoroquinolone resistance in the gyrA, gyrB, parC, and parE genes of Salmonella enterica serovar Typhi and serovar Paratyphi A were investigated. The sequences of the quinolone resistance-determining region of the gyrA gene in clinical isolates which showed decreased susceptibilities to fluoroquinolones had a single mutation at either the Ser-83 or the Asp-87 codon, and no mutations were found in the gyrB, parC, and parE genes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / pharmacology*
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DNA Gyrase / genetics*
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DNA Topoisomerase IV / genetics*
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Drug Resistance, Bacterial / genetics*
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Fluoroquinolones
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Mutation
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Salmonella paratyphi A / drug effects*
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Salmonella paratyphi A / enzymology
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Salmonella paratyphi A / genetics
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Salmonella typhi / drug effects*
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Salmonella typhi / enzymology
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Salmonella typhi / genetics
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Sequence Analysis, DNA
Substances
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Anti-Infective Agents
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Fluoroquinolones
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DNA Topoisomerase IV
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DNA Gyrase
Associated data
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GENBANK/AB071870
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GENBANK/AB071871
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GENBANK/AB071987
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GENBANK/AB072393
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GENBANK/AB072396
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GENBANK/AB072700
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GENBANK/AB072701
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GENBANK/AB072702