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Curr Opin Cell Biol. 2002 Oct;14(5):594-602.

Integrin signaling: it's where the action is.

Author information

1
Department of Stomatology, School of Dentistry, University of California San Francisco, 94143-0512, USA. damsky@cgl.ucsf.edu

Abstract

Recent advances highlight a critical role for integrin receptors for extracellular matrix in determining where in cells critical signals are transduced. Integrins are shown to activate signaling intermediates at specific surface membrane locations, to promote nuclear translocation of factors that activate gene transcription, and to recruit and augment the signaling power of receptors for growth factors.

PMID:
12231355
DOI:
10.1016/s0955-0674(02)00368-x
[Indexed for MEDLINE]

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