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Curr Opin Cell Biol. 2002 Oct;14(5):581-6.

Selectins: lectins that initiate cell adhesion under flow.

Author information

1
Oklahoma Medical Research Foundation, and Department of Biochemistry and Molecular Biology, Oklahoma Center for Medical Glycobiology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA. rodger-mcever@omrf.ouhsc.edu

Abstract

Interactions of selectins with cell-surface glycoconjugates mediate tethering and rolling adhesion of leukocytes and platelets on vascular surfaces. Recent studies have helped elucidate the molecular details of selectin-ligand interactions, the biosynthetic pathways for constructing selectin ligands, and the biophysical and cell biological features that modulate selectin-dependent rolling under flow.

PMID:
12231353
DOI:
10.1016/s0955-0674(02)00367-8
[Indexed for MEDLINE]

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