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Curr Opin Cell Biol. 2002 Oct;14(5):537-45.

Desmosomal cadherins.

Author information

1
School of Biological Sciences, University of Manchester, UK. david.garrod@man.ac.uk

Abstract

New evidence from blocking desmosomal adhesion with anti-adhesion peptides reveals a role for desmosomes in cell positioning in morphogenesis. Desmosomal adhesion is necessary for the stability of adherens junctions in epithelial cell sheets. Knockout and mis-expression of desmosomal cadherins in mice suggests that they may function directly or indirectly in regulating epidermal differentiation. Protein kinase C signalling and tyrosine phosphorylation appear to regulate desmosomal adhesion. There are new insights into the role of desmosomal cadherins in autoimmune, infectious and genetic disease.

PMID:
12231347
DOI:
10.1016/s0955-0674(02)00366-6
[Indexed for MEDLINE]

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