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Curr Opin Cell Biol. 2002 Oct;14(5):531-6.

Claudin-based barrier in simple and stratified cellular sheets.

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Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida-Konoe, Sakyo-ku, Kyoto, Japan.


For homeostasis in multicellular organisms, isolation and compartmentalisation of the internal environment are essential, and are established by various cellular sheets. For these cellular sheets to function as barriers, the intercellular route must be sealed. Recent advances reveal that claudins - major cell adhesion molecules in tight junctions - are directly involved in this intercellular sealing, not only in simple but also in stratified cellular sheets in vertebrates.

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