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Eur Psychiatry. 2002 Jul;17(4):232-3.

Efficacy of lithium treatment in Kleine-Levin syndrome.

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Division of Child Neurology and Psychiatry, University of Pisa (Italy), IRCCS Stella Maris, Via dei Giacinti 2, 56018 Calambrone (Pi), Italy.


The Kleine-Levin syndrome (KLS) is characterized by periodic, sudden-onset episodes of hypersomnia, compulsive hyperphagia, and behavioral-emotional symptoms, lasting from a few days to a few weeks, with complete remission in the intercritical periods. We report on efficacy of lithium treatment in a highly recurring form of the disorder in a 17-year-old male adolescent. The decreasing severity of the disorder paralleled the progressive increase of lithium dosage, up to 0.9 mEq l(-1). Implications regarding the pharmacological treatment of this neglected disorder are discussed.

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