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Cell. 2002 Sep 6;110(5):575-85.

OcaB is required for normal transcription and V(D)J recombination of a subset of immunoglobulin kappa genes.

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1
Laboratory of Molecular Immunology, New York, NY 10021, USA.

Abstract

OcaB, a transcriptional coactivator also known as Bob-1 or OBF-1, was isolated on the basis of its ability to enhance transcription of immunoglobulin (Ig) genes in vitro. Paradoxically, OcaB(-/-) mice showed no apparent deficiency in Ig gene transcription, only cellular immune defects including absence of germinal centers (GC) and decreased numbers of immature B cells; the genes targeted by OcaB were not determined. Here we report that OcaB is essential for V(D)J recombination of a subset of Igkappa genes. We show that OcaB modulates recombination by directly enhancing Igkappa gene transcription in vivo.

PMID:
12230975
DOI:
10.1016/s0092-8674(02)00911-x
[Indexed for MEDLINE]
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