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Hum Gene Ther. 2002 Sep 1;13(13):1571-81.

Oral administration of recombinant adeno-associated virus elicits human immunodeficiency virus-specific immune responses.

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Department of Bacteriology, Yokohama City University School of Medicine, Yokohama 236-0004, Japan.


Oral vaccines can induce both systemic and mucosal immunity. Mucosal immunity, especially regional cell-mediated immunity, plays an important role in protecting individuals from infectious diseases such as acquired immunodeficiency syndrome. In this study, a recombinant adeno-associated virus vector expressing human immunodeficiency virus type 1 env gene (AAV-HIV) was orally administered to BALB/c mice. Systemic and regional immunity was induced in the mice. Furthermore, the immunization significantly reduced viral load after an intrarectal challenge with a recombinant vaccinia virus expressing HIV env gene. Moreover, we also show that dendritic cells might contribute to the AAV-HIV vector-induced immune responses.

[Indexed for MEDLINE]

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