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Gynecol Endocrinol. 2001 Dec;15 Suppl 6:22-8.

Current place of progestins in the treatment of endometriosis-related complaints.

Author information

1
Department of Obstetrics and Gynecology, Ammerland Clinic GmbH, Academic Teaching Hospital of the University of Göttingen, Westerstede, Germany.

Abstract

Oral progestins have been used for the treatment of endometriosis and endometriosis-associated complaints for more than 40 years. The mechanism of action on the menstrual cycle is well understood; however, the mechanism of action on endometriosis is still a matter of debate. The different progestins are able to stop proliferation in endometriotic implants and to induce regressive change to certain degrees; they are not able to heal endometriosis because endometriosis is a chronic and recurrent disease. For this reason, no medical treatment can heal endometriosis and repeat medication is necessary in the medical management of this disease. Progestins--especially non-androgenic progestins--are well tolerated and have only few side-effects; they can be used repeatedly or continuously over a long period of time.

PMID:
12227883
[Indexed for MEDLINE]

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