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Schizophr Res. 2002 Oct 1;57(2-3):209-19.

Predictors of medication discontinuation by patients with first-episode schizophrenia and schizoaffective disorder.

Author information

1
Department of Psychiatry Research, Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, New York 11004, USA. robinson@lij.edu

Abstract

BACKGROUND:

Enhancing medication adherence early in the course of schizophrenia and schizoaffective disorder may substantially improve long-term course. Although extensively studied in multi-episode patients, little data exist on medication adherence by first-episode patients.

METHOD:

Medication adherence was assessed during the first year of treatment and following recovery from the first relapse in patients treated by a standardized medication algorithm.

RESULTS:

During the first year of treatment, patients with poorer premorbid cognitive functioning were more likely to stop antipsychotics (t=-2.54, df=75, p=0.01). Parkinsonian side effects increased the likelihood (hazard ratio=41.22; 95% CI=2.30, 737.89; p=0.01), and better executive function decreased the likelihood (hazard ratio=0.40; 95% CI=0.18, 0.88; p=0.02) that patients discontinued maintenance medication after a first relapse.

CONCLUSION:

Interventions to ameliorate cognitive deficits and Parkinsonian side effects may enhance treatment adherence.

PMID:
12223252
[Indexed for MEDLINE]
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