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Breast Cancer Res. 2002;4(5):176-8. Epub 2002 Jul 19.

A new model for ductal carcinoma in situ suggests strategies for treatment.

Author information

1
Department of Biosciences, University of Kent at Canterbury, UK. W.J.Gullick@ukc.ac.uk

Abstract

Human ductal carcinoma in situ (DCIS) of the breast is now diagnosed quite frequently, due largely to the introduction of mammographic screening. It has been shown in a cell culture system that activation of c-erbB-2, but not the epidermal growth factor receptor, results in a DCIS-like phenotype. Since overexpression of c-erbB-2 occurs in 60% of DCIS, this suggests that it could be a target for treatment in this disease.

PMID:
12223119
PMCID:
PMC138739
[Indexed for MEDLINE]
Free PMC Article

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