Transfer of knowledge from the basic biopsychosocial sciences to patient care is a major task for dental students during their education. Computer-based interactive patient simulations can help students affect this transfer because simulations allow students to develop and practice problem solving and decision-making skills interactively within the context of patient problems. A program for authoring computer-based interactive simulations is described. Patient simulations can effectively integrate basic science relevance, preparation for clinical problem solving, teaching new clinical content and several other necessary elements into curriculum infrastructure. Case simulations also can contribute to evolving educational standards set out by accrediting bodies.