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Am J Hematol. 2002 Sep;71(1):33-6.

High-titer acquired factor V inhibitor responsive to corticosteroids and cyclophosphamide in a patient with two malignant tumors.

Author information

1
Hematology Laboratory, Créteil Intercommunal Hospital Center, France. nazanine.bayani@chicreteil.fr

Abstract

We report a 79-year-old man with two simultaneous malignant tumors (buccal epidermoid carcinoma and prostatic adenocarcinoma) who developed a severe bleeding complication at the site of the buccal tumor as well as a massive cerebral hematoma after a skull trauma. Laboratory findings showed the presence of a high-titer specific factor V inhibitor. The patient failed to respond to intravenous immunoglobulins, but both clinical and laboratory improvement was obtained after treatment with corticosteroids and cyclophosphamide.

PMID:
12221671
DOI:
10.1002/ajh.10172
[Indexed for MEDLINE]
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