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Rofo. 2002 Sep;174(9):1154-7.

[Secretin-stimulated MR cholangiopancreatography (MRCP): visualization of the normal pancreatic duct in comparison with ERCP].

[Article in German]

Author information

1
Klinik für Strahlendiagnostik, Medizinisches Zentrum für Radiologie, Philipps Universität, Marburg. heverhag@post.med.uni-marburg.de

Abstract

PURPOSE:

To determine whether the application of secretin improves the depiction of the normal pancreatic duct and to document the time course of any possible improved visualisation.

PATIENTS AND METHODS:

Twenty-eight patients with a normal pancreatic ductal system, proved by ERCP, were prospectively enrolled in our study. MRCP was carried out in a 1.0 Tesla unit using a thick slab single-shot turbo-echo sequence (TR: infinity, TE: 1100 ms, FA: 150 degrees, slab thickness: 65 mm). Following acquisition of a non-enhanced image, 1 clinical unit/kg bodyweight of secretin was injected intravenously. During the subsequent ten minutes the MR measurement was repeated every 30 seconds. The images were independently evaluated by two investigators.

RESULTS:

The improvement in quality after administration of secretin was statistically significant for both investigators (p < 0.05), but no significant difference was found between both investigators concerning the quality of the images (p = 0.49). Prior to the secretin application, the entire ductal system only be evaluated in ten cases (35.7 %) by both investigators, afterwards in 26 cases (92.9 %). Improvement was achieved after a mean time of 1.5 minutes and lasted until the ninth minute.

CONCLUSION:

Intravenous application of secretin improves image quality of MRCP also in patients with no pancreatic pathology. Improvement begins after 1.5 minutes and lasts for about seven minutes.

PMID:
12221575
DOI:
10.1055/s-2002-33944
[Indexed for MEDLINE]

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