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Mol Biol Cell. 2002 Sep;13(9):3336-43.

A Ypt32p exchange factor is a putative effector of Ypt1p.

Author information

1
Howard Hughes Medical Institute and the Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06519-1418, USA.

Abstract

Ypt1p regulates vesicle tethering and fusion events from the ER to the Golgi and through the early Golgi. Genetic studies have suggested a functional relationship between Ypt1p and Ypt31p/Ypt32p. Ypt31p and Ypt32p are a pair of functionally redundant GTPases that act after Ypt1p to mediate intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi. Here we report that a novel Ypt32p exchange factor is a putative effector of Ypt1p. These findings implicate small GTP-binding proteins of the Ypt/Rab family in a signal cascade that directs membrane traffic through the secretory pathway.

PMID:
12221137
PMCID:
PMC124163
DOI:
10.1091/mbc.01-12-0577
[Indexed for MEDLINE]
Free PMC Article

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