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Arch Otolaryngol Head Neck Surg. 2002 Sep;128(9):1089-95.

Clear cell odontogenic carcinoma: report of a case and analysis of the literature.

Author information

1
Department of Pathology, Box 1189, Mount Sinai Medical Center, New York, NY, USA.

Abstract

BACKGROUND:

Clear cell odontogenic carcinoma (CCOC), which has been described within the past 2 decades, is a rare odontogenic tumor that tends to occur in the mandible of older adults, with a predilection for women. It is potentially aggressive and capable of multiple local recurrences and locoregional and distant metastases.

OBJECTIVES:

To report the clinicopathologic findings and follow-up of a case of CCOC and to review the literature.

DESIGN:

Case report and literature review.

MAIN OUTCOME MEASUREMENTS:

Findings from histologic analysis, immunohistochemistry, and electron microscopy.

RESULTS:

An 81-year-old woman experienced 3 locoregional recurrences within 21 months of initial therapy. She is presently disease free, 4.5 years after initial resection, having received multiple resections and adjuvant radiotherapy.

CONCLUSIONS:

The diagnosis of CCOC must be considered in the differential diagnosis of jaw tumors with a clear cell component. For these tumors, resection with negative margins is the treatment of choice because more conservative surgery (eg, curettage) inevitably results in recurrence and/or metastasis. Adjuvant radiotherapy is a rational option for tumors that have eroded cortex.

PMID:
12220218
[Indexed for MEDLINE]

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