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J S Afr Vet Assoc. 2001 Dec;72(4):214-6.

Some clinical effects of midazolam premedication in propofol-induced and isoflurane-maintained anaesthesia in dogs during ovariohysterectomy.

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Department of Companion Animal Surgery, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.


In a randomised, placebo-controlled clinical trial, anaesthesia was induced with propofol (4 mg/kg) after intravenous premedication with or without midazolam (0.1 mg/kg), in a group of 8 dogs scheduled for ovariohysterectomy. Midazolam administration induced acute behavioural changes, and increased reflex suppression after propofol induction. Compared to the control group, the dose required to obtain loss of the pedal reflex was significantly reduced by 37%, and the end-tidal isoflurane concentration during maintenance, reduced by 23%.

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