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Nat Genet. 2002 Oct;32(2):254-60. Epub 2002 Sep 3.

Evidence for two apoptotic pathways in light-induced retinal degeneration.

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1
Division of Biology, California Institute of Technology, Pasadena, California 91125, USA.

Abstract

Excessive phototransduction signaling is thought to be involved in light-induced and inherited retinal degeneration. Using knockout mice with defects in rhodopsin shut-off and transducin signaling, we show that two different pathways of photoreceptor-cell apoptosis are induced by light. Bright light induces apoptosis that is independent of transducin and accompanied by induction of the transcription factor AP-1. By contrast, low light induces an apoptotic pathway that requires transducin. We also provide evidence that additional genetic factors regulate sensitivity to light-induced damage. Our use of defined mouse mutants resolves some of the complexity underlying the mechanisms that regulate susceptibility to retinal degeneration.

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PMID:
12219089
DOI:
10.1038/ng984
[Indexed for MEDLINE]
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