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Mol Immunol. 2002 Sep;38(16-18):1235-8.

Phospholipid scramblase, a new effector of FcepsilonRI signaling in mast cells.

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INSERM U 485, Institut Pasteur, 25 rue du Dr. Roux, 75015, Paris, France.


The signaling network of the high-affinity receptor for IgE in mast cells involves tyrosine phosphorylation of a number of proteins. Here we report evidence that phospholipid scramblase, a protein involved in the distribution of phospholipids between the two leaflets of the plasma membrane, is a target for tyrosine kinases in this signal. The implication of this observation is briefly discussed.

[Indexed for MEDLINE]

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