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J Alzheimers Dis. 1999 Nov;1(4-5):265-74.

Estradiol: a protective and trophic factor in the brain.

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Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY 40536-0298, USA.


In recent years our appreciation that estradiol is truly a pleiotropic hormone has grown dramatically. We will review the findings that suggest that estrogens may exert important non-reproductive actions on the brain. These studies provide important insights into the clinical effects of estrogen replacement therapy on age- and disease-related processes in the brain. We will also discuss the multiple cellular and molecular mechanisms that may underlie estradiol's neurotrophic and neuroprotective effects.


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