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J Alzheimers Dis. 2001 Apr;3(2):191-193.

Peering into proteolysis with presenilins.

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Department of Pharmacology, Loyola University Medical Center, Maywood, IL, USA.


Presenilins were originally identified because they cause a neurodegenerative disease, but the impact of these proteins on the neuron appears to extend beyond neurodegeneration and into fundamental concepts of cell biology and development. Presenilins were identified as a result of the steady march of molecular genetics which first lead to identification of loci on chromosomes 1 and 14 that segregated with the phenotype of early onset familial Alzheimer Disease (AD), and then to discovery of the genes coding for PS1 and PS2.


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