Format

Send to

Choose Destination
J Alzheimers Dis. 2001 Apr;3(2):191-193.

Peering into proteolysis with presenilins.

Author information

1
Department of Pharmacology, Loyola University Medical Center, Maywood, IL, USA.

Abstract

Presenilins were originally identified because they cause a neurodegenerative disease, but the impact of these proteins on the neuron appears to extend beyond neurodegeneration and into fundamental concepts of cell biology and development. Presenilins were identified as a result of the steady march of molecular genetics which first lead to identification of loci on chromosomes 1 and 14 that segregated with the phenotype of early onset familial Alzheimer Disease (AD), and then to discovery of the genes coding for PS1 and PS2.

PMID:
12214060

Supplemental Content

Full text links

Icon for IOS Press
Loading ...
Support Center