Format

Send to

Choose Destination
Growth Horm IGF Res. 2002 Oct;12(5):342-58.

Pharmacokinetics and acute lipolytic actions of growth hormone. Impact of age, body composition, binding proteins, and other hormones.

Author information

1
Medical Department M (Endocrinology and Diabetes) Aarhus University Hospital, DK-8000 Aarhus C, Denmark. tkh@dadlnet.dk

Abstract

The biologic actions of endogeneous growth hormone (GH) depend on its secretion and clearance rates as well as sensitivity at the receptor level. Aberrations in GH pharmacokinetics and pharmacodynamics may occur with increasing age, and have been implicated in diseases such as obesity, diabetes mellitus, and critical illness. In this review, recent insights into the association between GH metabolism and age, body composition, binding proteins and other hormones are discussed.

PMID:
12213188
DOI:
10.1016/s1096-6374(02)00061-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center