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Head Neck. 2002 Sep;24(9):850-8.

Clinical significance of interleukin-6 and interleukin-6 receptor expressions in oral squamous cell carcinoma.

Author information

1
Department of Otolaryngology, Taipei-Veterans General Hospital, 201, Sec. 2, Shih-Pai Road, Taipei, Taiwan.

Abstract

BACKGROUND:

Recent studies showed that interleukin-6 (IL-6) played a role in tumor development. However, available information about the prognostic significance of IL-6 and IL-6 receptors (IL-6R) for oral squamous cell carcinoma (OSCC) is limited.

METHODS:

Eighty-six patients with OSCC were enrolled. Immunohistochemical staining was used to determine IL-6R expression and in-situ hybridization for IL-6 mRNA transcripts in surgical specimens. Clinicopathologic correlation was evaluated by chi-square test and survival by log rank test.

RESULTS:

Expression rates of IL-6R and IL-6 mRNA transcripts in tumor specimens were 73.3% and 54.7%, much higher than those in nontumor mucosa (p <.001). IL-6R overexpression was associated with larger tumors and more advanced histologic grade (p <.05). The presence of IL-6 mRNA transcripts was inversely correlated with distant metastasis, lymph node involvement, and second primary SCC (p <.05) and predicted better survival (p =.007).

CONCLUSIONS:

IL-6-IL-6R coexpression was rather high in OSCC, and IL-6 mRNA transcript expression might influence patient survival. The biologic role of IL-6-IL-6R coexpression in OSCC needs additional investigation.

PMID:
12211049
DOI:
10.1002/hed.10145
[Indexed for MEDLINE]

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