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Stat Med. 2002 Aug 30;21(16):2313-24.

Network meta-analysis for indirect treatment comparisons.

Author information

1
Department of Biostatistics, University of Washington, Box 357232, Seattle, WA 98195-7232, USA. tlumley@u.washington.edu

Abstract

I present methods for assessing the relative effectiveness of two treatments when they have not been compared directly in a randomized trial but have each been compared to other treatments. These network meta-analysis techniques allow estimation of both heterogeneity in the effect of any given treatment and inconsistency ('incoherence') in the evidence from different pairs of treatments. A simple estimation procedure using linear mixed models is given and used in a meta-analysis of treatments for acute myocardial infarction.

PMID:
12210616
DOI:
10.1002/sim.1201
[Indexed for MEDLINE]

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