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Bioessays. 2002 Sep;24(9):821-7.

Molecular control of neuronal migration.

Author information

1
Department of Pediatrics, and Molecular Biology and Pharmacology, Box 8108, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

Abstract

Our understanding of neuronal migration has been advanced by multidisciplinary approaches. At the cellular level, tangential and radial modes of neuronal migration contribute to different populations of neurons and have differential dependence on glial cells. At the molecular level, extracellular guidance cues have been identified and intracellular signal transduction pathways are beginning to be revealed. Interestingly, mechanisms guiding axon projection and neuronal migration appear to be conserved with those for chemotactic leukocytes.

PMID:
12210518
PMCID:
PMC2031209
DOI:
10.1002/bies.10141
[Indexed for MEDLINE]
Free PMC Article

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