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Bioessays. 2002 Sep;24(9):780-4.

When machines get stuck--obstructed RNA polymerase II: displacement, degradation or suicide.

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Department of Cell Biology and Genetics, Medical Genetic Center, Erasmus University Rotterdam, The Netherlands.


The severe hereditary progeroid disorder Cockayne syndrome is a consequence of a defective transcription-coupled repair (TCR) pathway. This special mode of DNA repair aids a RNA polymerase that is stalled by a DNA lesion in the template and ensures efficient DNA repair to permit resumption of transcription and prevent cell death. Although some key players in TCR, such as the Cockayne syndrome A (CSA) and B (CSB) proteins have been identified, the exact molecular mechanism still remains illusive. A recent report provides new unexpected insights into TCR in yeast. The identification and characterisation of a novel protein co-purifying with the yeast homologue of CSB (Rad26) imposes reassessment of our current understanding of TCR in yeast. What about humans?

[Indexed for MEDLINE]

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