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Nat Rev Cancer. 2002 Sep;2(9):705-13.

How acute promyelocytic leukaemia revived arsenic.

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1
CNRS UPR 9051, Laboratoire associé du comité de Paris de la ligue contre le cancer, affilié à l'université de Paris VII, Hôpital St Louis, 1 avenue C. Vellefaux, 75475 Paris cedex 10, France.

Abstract

Despite its many therapeutic qualities, arsenic trioxide has been more commonly remembered as Madame Bovary's poison than as an anticancer drug. The ability of arsenic trioxide to treat acute promyelocytic leukaemia has radically changed this view, providing new insights into the pathogenesis of this malignancy and raising hopes that arsenicals might be useful in treating other cancers.

PMID:
12209159
DOI:
10.1038/nrc887
[Indexed for MEDLINE]
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