WASp in immune-system organization and function

Nat Rev Immunol. 2002 Sep;2(9):635-46. doi: 10.1038/nri884.

Abstract

The regulation of many immunological events depends on systems that mediate dynamic actin reorganization in response to signals from the cell membrane. The Wiskott-Aldrich syndrome protein (WASp) is the founding member of a family of proteins that have emerged as crucial effectors of Rho GTPases and activators of the cytoskeletal-organizing complex Arp2/3. Now, WASp has been shown to be intimately involved in many pathways that influence the function of the immune system. Disturbances in these systems result in the complex immunodysregulation of Wiskott-Aldrich syndrome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin-Related Protein 2
  • Actin-Related Protein 3
  • Actins / metabolism
  • Animals
  • Blood Cells / physiology
  • Cell Membrane / immunology
  • Cytoskeletal Proteins / biosynthesis
  • Humans
  • Lymphocytes / immunology
  • Microfilament Proteins / chemistry
  • Microfilament Proteins / immunology
  • Microfilament Proteins / physiology
  • Nerve Tissue Proteins / deficiency
  • Nerve Tissue Proteins / immunology
  • Nerve Tissue Proteins / physiology
  • Phagocytosis
  • Proteins / chemistry
  • Proteins / immunology
  • Proteins / physiology*
  • Signal Transduction
  • Wiskott-Aldrich Syndrome / blood
  • Wiskott-Aldrich Syndrome / immunology*
  • Wiskott-Aldrich Syndrome / therapy
  • Wiskott-Aldrich Syndrome Protein
  • Wiskott-Aldrich Syndrome Protein Family
  • Wiskott-Aldrich Syndrome Protein, Neuronal
  • rho GTP-Binding Proteins / biosynthesis

Substances

  • ACTR2 protein, human
  • ACTR3 protein, human
  • Actin-Related Protein 2
  • Actin-Related Protein 3
  • Actins
  • Cytoskeletal Proteins
  • Microfilament Proteins
  • Nerve Tissue Proteins
  • Proteins
  • WAS protein, human
  • WASL protein, human
  • Wiskott-Aldrich Syndrome Protein
  • Wiskott-Aldrich Syndrome Protein Family
  • Wiskott-Aldrich Syndrome Protein, Neuronal
  • rho GTP-Binding Proteins