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Nat Rev Immunol. 2002 Sep;2(9):635-46.

WASp in immune-system organization and function.

Author information

1
Molecular Immunology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK. a.thrasher@ich.ucl.ac.uk

Abstract

The regulation of many immunological events depends on systems that mediate dynamic actin reorganization in response to signals from the cell membrane. The Wiskott-Aldrich syndrome protein (WASp) is the founding member of a family of proteins that have emerged as crucial effectors of Rho GTPases and activators of the cytoskeletal-organizing complex Arp2/3. Now, WASp has been shown to be intimately involved in many pathways that influence the function of the immune system. Disturbances in these systems result in the complex immunodysregulation of Wiskott-Aldrich syndrome.

PMID:
12209132
DOI:
10.1038/nri884
[Indexed for MEDLINE]

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