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Nat Rev Mol Cell Biol. 2002 Sep;3(9):710-8. doi: 10.1038/nrm911.

Cyclic nucleotide research -- still expanding after half a century.

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1
Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280, USA. beavo@u.washington.edu

Abstract

Since the discovery in 1957 that cyclic AMP acts as a second messenger for the hormone adrenaline, interest in this molecule and its companion, cyclic GMP, has grown. Over a period of nearly 50 years, research into second messengers has provided a framework for understanding transmembrane signal transduction, receptor-effector coupling, protein-kinase cascades and downregulation of drug responsiveness. The breadth and impact of this work is reflected by five different Nobel prizes.

PMID:
12209131
DOI:
10.1038/nrm911
[Indexed for MEDLINE]
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