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Nat Rev Mol Cell Biol. 2002 Sep;3(9):673-84.

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling.

Author information

1
Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Building 560, Room 22-12, Fort Detrick, Frederick, Maryland 21702, USA. fortini@ncifcrf.gov

Abstract

Many cell-surface receptors transmit signals to the nucleus through complex protein cascades. By contrast, the Notch signalling pathway uses a relatively direct mechanism, in which the intracellular domain of the receptor is liberated by intramembrane cleavage and translocates to the nucleus. This critical cleavage is mediated by the gamma-secretase complex, and new findings reveal that this mechanism is used by various receptors, although many questions remain about the biochemical details.

PMID:
12209127
DOI:
10.1038/nrm910
[Indexed for MEDLINE]

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