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Nat Rev Mol Cell Biol. 2002 Sep;3(9):663-72.

Mixed-lineage kinase control of JNK and p38 MAPK pathways.

Author information

1
Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA. gallok@msu.edu

Abstract

Mixed-lineage kinases (MLKs) are serine/threonine protein kinases that regulate signalling by the c-Jun amino-terminal kinase (JNK) and p38 mitogen-activated-protein kinase (MAPK) pathways. MLKs are represented in the genomes of both Caenorhabditis elegans and Drosophila melanogaster. The Drosophila MLK Slipper regulates JNK to control dorsal closure during embryonic morphogenesis. In mammalian cells, MLKs are implicated in the control of apoptosis and are potential drug targets for many neurodegenerative diseases.

PMID:
12209126
DOI:
10.1038/nrm906
[Indexed for MEDLINE]

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