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Nat Immunol. 2002 Sep;3(9):807-13.

Natural killer cell activation in mice and men: different triggers for similar weapons?

Author information

1
Unit of Cytokines and Lymphoid Development, The Pasteur Institute, Paris, France. cecco@pasteur.fr

Abstract

The signaling pathways that regulate B and T lymphocytes are remarkably conserved between humans and mice. However, recent evidence suggests that the pathways regulating natural killer (NK) cell activation may actually differ between these two species. We discuss the controversies in the field and propose that this divergence could be deceptive: despite some clear differences between human and mouse NK cell receptors, the many ways of activating NK cells and their functions may well be conserved.

PMID:
12205470
DOI:
10.1038/ni0902-807
[Indexed for MEDLINE]

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